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There was no difference in response to Lexapro between men and women. The long-term usefulness of the drug for the individual patient. Lexapro works by increasing the available supply of serotonin, Escitalopram improves symptoms of depression. Lexapro is an antidepressant in a group of drugs called selective serotonin reuptake inhibitor used to treat depression and generalized anxiety disorder. Lexapro is an antidepressant in a group of drugs called selective serotonin reuptake inhibitor used to treat anxiety and major depressive disorder. If you experience Lexapro side effects continue or are bothersome, check with your doctor.